51 results
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Associated with Joint Pain ... • Rheumatic fever ... Sarcoidosis #dermatology ... #rashes #differential ... #diagnosis #rheumatology
Neurological Manifestations of Tuberculosis
Spinal Arachnoiditis & Polyradiculopathy:
 • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
wasting, radicular pain ... symptoms, fever ... ) • Headache, fever ... Meningitis: • Fever ... Tuberculosis #diagnosis #differential
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
Infections 2. ... symptoms - Headache, fever ... Nausea, abdominal pain ... Urticaria #diagnosis #rheumatology ... #comparison #table
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
- Due to Viral infection ... younger pts) Differential ... Symptoms: High fevers ... chills, flank pain ... hemolytic #anemia #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... SLE) - Viral infections ... mountain spotted fever ... #Diagnosis #hematology ... #rheumatology #
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Autoimmune: Warm AIHA, Cold ... Defects, Drugs, Liver ... Internal (RBC) - Infections ... #Diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... Extrinsic Causes: • Liver ... • AIHA: warm, cold ... drug induced • Infections ... classification #hematology
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Hyperthyroidism Fever ... • Rheumatic fever ... SLE, Rheumatic fever ... • New murmur, fever ... #differential #
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia - Differential ... Agglutination - Cold ... inclusions - If infection ... bartonella (oroya fever ... Algorithm #workup #hematology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
- Arthritis Differential ... - Autoimmune Rheumatologic ... • Rheumatic fever ... streptococci (rheumatic fever ... #Differential #