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diagnosis management hematology syndrome erythematosus joint oncology pain sle algorithm causes classification dermatology infectiousdiseases lung systemic vasculitis abscess activation adultonset
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Malar rash 40% - Fever ... (aPL) 30-45% Differential ... Other auto-immune, Infectious ... symptoms #mimickers #differential ... #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... SLE], AOSD) • Infection ... Treatment: • Corticosteroids
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Cough, Dyspnea, Fever ... symptomatology Differential ... Complex: Systemic lupus ... allopurinol), Infection ... DAH, rule out infection
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad: Fever ... fraction < 20% Differential ... Diaqnoses: • Infectious ... hepatitis • Pulmonary ... #rheumatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
parvovirus B19 infection ... • Rheumatic fever ... lesions • Discoid lupus ... #skin #rashes #differential ... #diagnosis #rheumatology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
to think about lupus ... the face (many differential ... 9) Unexplained fever ... , when infection ... erythematosus #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Hyperthyroidism Fever ... • Rheumatic fever ... SLE, Rheumatic fever ... stenosis - Rheumatic fever ... • New murmur, fever
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
respiratory symptoms • Fever ... symptoms • Rheumatologic ... , fever, chills, ... normal glucose level ... • Isolated fever
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia - Differential ... inclusions - If infection ... bartonella (oroya fever ... Diagnosis #Algorithm #workup ... #hematology #testing
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
acute rheumatic fever ... spondyloarthropathies, lupus ... Joint #Pain #MSK #rheumatology ... #approach #workup ... #differential #
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