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diagnosis anemia hemophagocytic lymphohistiocytosis treatment algorithm causes criteria syndrome aplastic blood hemeonc hemolytic hodgkins leukemia lymphoma product reactions activation adultonset
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Lymphohistiocytosis (HLH ... Clinical Features: Fever ... lab findings in HLH ... 8 criteria: • Fever ... Lymphohistiocytosis #diagnosis #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Lymphohistiocytosis (HLH ... following: • Fever ... lymph node, or liver ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Diagnostic criteria for Neutropenic Enterocolitis (NEC) Major Criteria: • Neutropenia (ANC <500 x 10^9 cells/L) • Bowel
30mm length) • Fever ... Diagnosis #criteria #hematology ... #oncology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... Renal Disease, Liver ... #Anemia #MCV #Classification ... #Differential # ... Algorithm #Causes #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH ... • Clinical: fever ... , ↓ Fibrinogen level ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
- Pel-Ebstein fever ... translocation • Types: Classification ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... Extrinsic Causes: • Liver ... Hemolytic #Anemia #Differential ... Diagnosis #causes #classification ... #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... mountain spotted fever ... Vasculopathy #Purpura #Differential ... #Diagnosis #hematology ... #rheumatology #
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
if neutropenic fever ... Anemia #diagnosis #management ... #treatment #hematology
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