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diagnosis differential management causes chronic anemia aplastic apml cll dermatology differentiation emergencies fuo gastroenterology gout hemeonc infections infectiousdiseases lymphocytic mycobacteria
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Causes of Fever ... tuberculosis, Abscess ... Lemierre's syndrome ... Malignancy: - Hematologic ... malignancies: Lymphoma, Leukemia
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
characterized by fever ... Disorder: - Fever ... Symptoms: - Fever ... arthralgia) - Fever ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Headaches, bone pain, fever ... , weight loss, abdominal ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... microglobulin Treatment ... • Sezary syndrome ... diagnosis #workup #oncology ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... virus (EBV) • Leukemia ... index < 2 • EPO Level ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Chronic Abdominal Pain Causes - Differential Diagnosis Framework Many patients with chronic abdominal pain have had prior
Red Flags: • Fever ... • Budd-Chiari syndrome ... • Splenomegaly/Abscess ... infarction • Lymphoma/Leukemia ... Irritable bowel syndrome
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Subacute-Acute: • Common: fever ... diagnosis #management #hematology ... #oncology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Neutropenic fever ... : - Fever + ANC ... ): - Hematologic ... or HSCT - CRS: fever ... therapy - Symptoms: fever
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Hematologic malignancy ... Presentation: Fever ... enzymes, diarrhea, abdominal ... Manifestations: • Fever ... • Fever and weight
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
sex • Metabolic syndrome ... 12-24 Hours • Fever ... not possible • Ultrasound ... • Serum urate level ... #rheumatology
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