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diagnosis differential rheumatology algorithm causes liver treatment dermatology secondary workup atlas leukemia monoclonal abnormal aplastic cirrhosis clinical disease gastroenterology generalized
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Chronic disease ... anemia (sometimes ... myeloma Rouleaux: Chronic ... Multiple myeloma, Chronic ... differential #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Scoring system: ... • Neutropenia, anemia ... diagnosis #workup #oncology ... #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Myelodysplastic syndrome ... cells - Sickle cell ... Hemolytic uremic syndrome ... #differential #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... cytopenias (usually anemia ... Allogeneic stem cell ... #treatment #hematology ... #oncology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
of chronic inflammation ... of chronic kidney ... : Alcohol use, Liver ... Myelodysplastic syndrome ... diagnosis #causes #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... hemorrhage) • Chronic ... Myelodysplastic syndrome ... myeloid leukemia (CML ... Diagnosis #Causes #hematology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Iron deficiency anemia ... discoloration) • Liver ... discoloration) • Chronic ... • Nephrotic syndrome ... #Secondary #dermatology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Consider stem cell ... if neutropenic fever ... #diagnosis #management ... #treatment #hematology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... in those with CLD ... #ACLF #Acute #Chronic ... #Cirrhosis #Hepatology ... gastroenterology #management
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