35 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Disease: Primary ... Cholangitis #pathophysiology ... #pbc #psc #hepatology ... #comparison
Signs of Chronic Liver Disease ( Cirrhosis )

#Diagnosis #Cirrhosis #Signs #Symptoms #Hepatology
Signs of Chronic ... Liver Disease ( ... Cirrhosis ) #Diagnosis ... #Cirrhosis #Signs ... #Symptoms #Hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... (LFTs) - Normal ... #Laboratory #Values ... Interpretation #diagnosis ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Framework: Liver ... Injury → liver ... #hepatology #algorithm ... Transaminitis #LFTs
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Liver Chemistry ... ALT: • AST: liver ... In liver, 80% of ... primarily within liver ... #Diagnosis #LFTs
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced Liver ... Chronic - ongoing ↑ LFTs ... or symptoms of liver ... disease 6-9 mo ... Drug #induced #Liver
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... Hepatocellular Level ... disease: > 2 ... #chemistry #diagnosis ... #differential #Hepatology
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
IBD • Chronic liver ... or kidney disease ... #Osteoporosis #pathophysiology ... #signs #symptoms ... #diagnosis
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... derangement of liver ... clinical symptoms/signs ... #LFTs #Abnormal ... #Algorithm #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... - Differential Diagnosis ... • Cholestatic disease ... • Others #LFTs ... #Hepatology #LiverEnzymes