18 results
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
Supportive with treatment ... hepatomegaly and anemia ... progressing to acute liver ... Liver transplant ... #differential #
Suspected Celiac Disease - Diagnosis Algorithm

Celiac disease suspected:
 • Signs and symptoms of celiac disease
 •
Iron-deficiency anemia ... unresponsive to treatment ... • Elevated liver ... autoimmune thyroiditis, hepatitis ... microscopic colitis Differential
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... Failure (ACLF) Clinical ... months without treatment ... disease, liver ... support, or liver
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Diagnosis Algorithm ... Renal Failure • Liver ... Hematologic • Anemia ... Epstein-Barr Virus • Hepatitis ... Obstructive Pulmonary Disease
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
from subclinical disease ... to acute liver ... hepatocellular pattern of liver ... Anti-LKM & Anti-ALC ... regarding need for treatment
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad ... fraction < 20% Differential ... hepatomegaly, hepatitis ... #diagnosis #management ... #treatment #rheumatology
Alcohol-related liver disease algorithm. 

In patients in whom alcohol is suspected to be the main injurious
Alcohol-related liver ... disease algorithm ... assessment of liver ... category according to liver ... ELF, enhanced liver
Shock - Differential Diagnosis Framework
 - MAP <65. SBP <90, drop in SBP > 40
 -
Shock - Differential ... Insufficiency, Liver ... , Severe Valve Disease ... #criticalcare #algorithm ... #treatment #management
Mild-to-Moderate Ulcerative Colitis - Management Algorithm
Curcumin:
 • Natural phytochemical from turmeric
 • 2g/day divided in 2-3
Potential GI SE, liver ... Nissle • VSL#3: ↑ clinical ... decreased dosing if liver ... disease • 5-ASA ... #treatment #IBD
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... • Liver diseases ... and hepatitis ... autoimmune hemolytic anemia ... Low serum IgG level