31 results
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... Clinical triad: Fever ... Prunelle Getten #AdultOnset ... diagnosis #management #treatment ... #rheumatology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Aplastic Anemia ... megaloblastic anemia Treatment ... if neutropenic fever ... Medicine @SCVMCMed #Aplastic ... #hematology
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's Disease ... synovitis (40%) Treatment ... BrighamChiefs #AdultOnset ... #Stills #Disease ... #AOSD #rheumatology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... Presentation: • Fever ... index < 2 • EPO Level ... anemia Treatment ... Anemia #oncology #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Non-hemolytic: ACD, Aplastic ... Non-megaloblastic: Liver ... disease, Alcoholism ... Differential #Diagnosis #hematology
Adult Onset Still's Disease - Yamaguchi Criteria
Major criteria:
 - Fever >= 39C lasting >= 1 weeks
Onset Still's Disease ... criteria: - Fever ... polyarteritis nodosa #AdultOnset ... #Stills #Disease ... #Major #Minor #Rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
highly inflammatory disease ... of underlying disease ... ALT ↑ bilirubin level ... Treatment: • Corticosteroids ... #Rheumatology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
Non-Hodgkin's Lymphoma - Comparison ... - Pel-Ebstein fever ... the spleen or liver ... #NonHodgkins #comparison ... #differential #hematology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Malabsorption (e.g. celiac disease ... ) • Advanced Liver ... Disease - Alcohol ... Summary #table #comparison ... #diagnosis #hematology
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
the population Disease ... Autoimmune diseases ... symptoms - Headache, fever ... Urticaria #diagnosis #rheumatology ... #comparison #table