11 results
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Aplastic Anemia ... megaloblastic anemia Treatment ... Supportive care (transfusions ... if neutropenic fever ... #hematology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
explain symptoms • Fever ... : 33% • Treatment ... : No • Treatment ... #Reactions #hematology ... #diagnosis #comparison
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
S/sx: Fever, flank ... have drop in Hct, fever ... Sx include: fever ... due to marrow aplasia ... diagnosis #management #hematology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
S/sx: Fever, flank ... have drop in Hct, fever ... Sx include: fever ... due to marrow aplasia ... diagnosis #management #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... Presentation: • Fever ... index < 2 • EPO Level ... anemia Treatment ... Anemia #oncology #hematology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad: Fever ... Prunelle Getten #AdultOnset ... diagnosis #management #treatment ... #rheumatology
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
: High spiking fever ... synovitis (40%) Treatment ... BrighamChiefs #AdultOnset ... Disease #AOSD #rheumatology ... diagnosis #management #treatment
PLATELETS Mnemonic for Causes of Thrombocytopenia

P - Platelet Disorders (DIC, ITP, TTP)
L - Leukemia, Lymphoma
A -
Lymphoma A - Aplastic ... Anemia T - Trauma, Transfusion ... Enlarged Spleen L - Liver ... Differential #Diagnosis #Hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Diuretics, PRBC transfusion ... - 80% have fever ... organ damage • Treatment ... Low calcium • Treatment ... diagnosis #management #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
incompatible blood transfusion ... DIC • Severe Liver ... + Bleeding Treatment ... hydration • RBC transfusion ... diagnosis #causes #treatment