12 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Hemolytic Anemias ... Macroangiopathic, Microangiopathic ... #Anemias #Differential ... #hematology
Anemia - Hemolysis Diagnostic Algorithm
Autoimmune hemolytic anemia
Microangiopathic hemolytic anemia
Probable thalassemia

Dr. Eric Strong @DrEricStrong - Strong Medicine
Anemia - Hemolysis ... Autoimmune hemolytic ... anemia Microangiopathic ... hemolytic anemia ... #hematology #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
hemolytic anemia ... thrombocytopenic purpura ... lymphoproliferative disorders ... Extravascular #Causes #differential ... #diagnosis #hematology
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
Often hard to differentiate ... thrombocytopenic #purpura ... #TTP #HemolyticUremicSyndrome ... thrombocytopenia #Comparison #Diagnosis ... #Table #Hematology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Differential Diagnosis ... #Hemolytic #Anemia ... #Diagnosis #Table ... #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... Diagnosis #hematology ... #rheumatology #
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Schistocyte: Microangiopathic ... Hemolytic Anemia ... hemolytic anemia ... hemolytic anemia ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider RBC membrane disorder ... elliptocytosis, autoimmune ... #Anemia #Differential ... #workup #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
: Autoimmune, Microangiopathic ... hemolytic anemia ... Production #Index #hematology ... #anemia #differential ... #diagnosis #calculation
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
malignancies • Anemia ... iron deficiency, hemolysis ... Chronic inflammatory disorders ... (e.g. autoimmune ... #hematology #secondary