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diagnosis differential causes management pulmonary chronic dyspnea hematology thrombocytosis acute amiodarone boop cancer cough crohns cryptogenic disease effusion erythematosus esophageal
Dyspnea - Considerations with Malignancy Directly Malignancy Related: - Lymphangitic spread to lung - Malignant pleural effusion
Considerations with Malignancy ... Directly Malignancy ... pleural effusion ... - Malignant pericardial ... - Cytopenias (anemia
Cough - Diagnostic Schema Infectious: URTI, LRTI, Bacterial, Viral Irritant/Exposure: Allergic, Post-infectious, Pneumonitis, ACEi, PTX, Foreign Body Airway Disease:
Disease: Asthma, COPD ... Autoimmune Vasculitis, ILD ... Malignancy: Lung ... Metastatic Dz, Malignant ... #Differential #Algorithm
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Inflammatory: • IBD ... Damage: • Post-op ... • Burns Non malignant ... Non-hematologic malignancy ... Iron deficiency anemia
Cryptogenic Organizing Pneumonia (COP) Cryptogenic Organizing Pneumonia Overview: • Idiopathic form of organizing pneumonia • formerly BOOP
with CTD, drugs, malignancy ... Rare: pleural effusions ... , pleural thickening ... Pulmonary lymphoma, Diffuse ... BOOP #pulmonary #ILD
Causes of Chronic Dyspnea - Differential Diagnosis Algorithm Pericardial • Effusion • Cardiac Tamponade* • Constriction Myocardial •
Differential Diagnosis Algorithm ... Pericardial • Effusion ... • Asthma • COPD ... Interstitium • ILD ... Pulmonary - Other • Anemia
Causes of Pleural Effusion - Differential Diagnosis Algorithm Transudate - Hydrostatic • Congestive heart failure • Constrictive
Causes of Pleural ... Diagnosis Algorithm ... Noninfectious: • Malignancy ... • Asbestos • Uremia ... #Diagnosis #Algorithm
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... concerning for malignancy ... hematology for workup ... hemolysis, deficiency anemia ... treatment • Malignancy
Esophageal Crohn's Disease Management Algorithm Assess for Active Symptoms and for Stricturing/Fistulizing Disease Stricturing DX: • Bx r/o
Disease Management Algorithm ... DX: • Bx r/o Malignancy ... Tx Inflammatory Comp ... • If Broncho/Pleural ... #treatment #IBD
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Infections • Malignancy ... pneumonitis • Diffuse ... Serositis: • Pleural ... lymphopenia, low PLT • Anemia ... rule in SLE Malignancy
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
and exudative pleural ... • Patchy or diffuse ... embolism - Malignancy ... Exclusion of other ILDs ... LDH • ↑ ESR, CRP
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