41 results
Ethacrynic acid - Conversion
Only loop diuretic without a sulfonamide substituent.
Rarely used alternative in patients who have
Ethacrynic acid - Conversion ... Only loop diuretic ... Ethacrynic #acid #Conversion ... #pharmacology #indications ... #diuretics #loop
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Diuretics sites ... . mannitol) 3) Loop ... diuretic (e.g. ... Metolazone) 5) Potassium-sparing ... pharmacology #nephrology #medications
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
Renal Loses - Medications ... - Loop and ... abnormalities - Hypercalcemia ... - Hypokalemia ... Causes #Workup #hypomg
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Summary of Diuretic ... empagliflozin LOOP ... DIURETICS • Furosemide ... Chlorthalidone POTASSIUM-SPARING ... #Medications #Pharmacology
Hyperkalemia Treatment Options
Stabilize cardiac membrane:
 • IV Calcium (peaks 5-10 minutes)
Decrease potassium concentration:
 • IV Fluids
Shift
Hyperkalemia Treatment ... Fluids Shift potassium ... renal function) - Loop ... diuretic (often ... LouLectures #Hyperkalemia
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... Diagnosis Algorithm ... Thyrotoxicosis Medications ... • Discontinued diuretic ... nephrology #low #potassium
Causes of Hypomagnesemia
Redistribution:
 - IV glucose
 - Correction of diabetic ketoacidosis
 - IV hyperalimentation
 - Refeeding
Saline or osmotic diuresis ... - Potassium depletion ... disease Drugs: - Loop ... #differential #medications ... #pharmacology #hypomg
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
associated with hypokalemia ... Furosemide and other loop ... diuretics ... hypomagnesemia #Medications ... nephrology #Causes #hypomg
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
Differential Diagnosis Algorithm ... Clinicians should also look ... Post-hypercapnia • Diuretics ... differential #diagnosis #algorithm ... causes #nephrology #potassium
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... Metolazone Loop ... Piretanide Potassium ... Pharmacology #nephrology #conversion ... #loop #thiazide