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diagnosis management lupus sle blood classification clinical comparison dermatology erythematosus oncology product syndrome systemic transfusion antinxp2 antinxp2dm bloodsmear borrelia cerebritis
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
- Transfusion Reactions ... without other cause ... : 33% • Treatment ... #hematology #diagnosis ... #comparison #table
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... Presents as dyspnea ... Hypothermia: Due to low ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... TRALI): Leading cause ... Presents as dyspnea ... Hypothermia: Due to low ... diagnosis #management #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Positive in 60-80% of cases ... 60-80% - Low ... life-threatening • Treatment ... Evolution: Chronic disease ... Management #Summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... autoantibodies that will cause ... Puncture, EEG Treatment ... #rheumatology # ... diagnosis #management #treatment
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
in >90% - Low ... 60-80% - Low ... Evolution: Chronic disease ... sle #comparison #table ... #rheumatology #
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... Pulm: Hypoxia, dyspnea ... , Elevated Cr, Low ... calcium • Treatment ... diagnosis #management #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Prolonged PT/PTT • Low ... • Severe Liver Disease ... Treat primary cause ... #treatment #management ... #hematology
Borrelia recurrentis on Peripheral Blood Smear 23M Somali refugee recently arrived w/severe abd pain, confusion and fever
The table below ... Given low sensitivity ... initiation of treatment ... Jarisch-Herxheimer reaction ... Infectious Diseases
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... (Granulomatous disease ... , drug reactions ... • Complement (Low ... differential #diagnosis #rheumatology
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