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algorithm oncology classification agglutinin atlas bloodcell calculation causes cll cold common cvid hemeonc hodgkins hypogammaglobulinemia immunodeficiency immunology index leukemia lymphocytic
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
-100): • Non-hemolytic ... , CKD • Hemolytic ... - Extrinsic: Autoimmune ... Non-megaloblastic: Liver disease ... Diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
kidney disease, ... Retroperitoneal, Uterine • Hemolysis ... hemolytic anemia ... Production #Index #hematology ... #anemia #differential
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
) - Differential ... of Chronic Disease ... • Bleeding • Hemolysis ... of Chronic Disease ... #Causes #Hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Membrane): - Autoimmune ... Defects: Sickle cell anemia ... Urobilinogen #Hemolysis ... Diagnosis #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Chronic disease ... Microangiopathic Hemolytic ... hemolytic anemia ... hemolytic anemia ... #diagnosis #hematology
General Approach to Anemia - Differential Diagnosis Framework 1) Check reticulocyte count to determine if hypo/hyper-proliferative 2) Exclude
- Differential ... hyper-proliferative 2) Exclude hemolysis ... haptoglobin) 3) Use MCV ... & clinical context ... diagnosis #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... immunophenotype Clinical ... chemotherapy for low-risk disease ... #oncology #hematology ... #management
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... • Compensated hemolysis ... intravascular hemolysis ... #hemolytic #anemia ... #hematology #diagnosis
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... #Diagnosis #hematology ... #nonpalpable #dermatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... Granulomatous lymphocytic ... hemolytic anemia ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
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