12 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... • Intrinsic RBC ... #Hemolytic #Intravascular ... #diagnosis #hematology ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Hemolysis - Differential ... • Cold AIHA ... - Hemolysis within ... anemia • ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... , Disseminated intravascular ... key #diagnosis #differential ... #hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
anemia (sometimes ... Microangiopathic Hemolytic ... spherocytosis, Autoimmune hemolytic ... autoimmune hemolytic ... #diagnosis #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... , Cold AIHA, Transfusion ... Defects: Sickle cell anemia ... Urobilinogen #Hemolysis ... Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic ... #Anemia #Differential ... #hematology #testing
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
for Hemolytic Anemia ... : warm, cold, drug ... udaygulati #Hemolytic ... #Anemia #Differential ... classification #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
• Symptoms of anemia ... Diagnosis: • hemolytic ... anemiaCold ... #hemolytic #anemia ... #hematology #diagnosis
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
hemorrhage and hemolysis ... result in severe anemia ... hemolysis Platelet ... anemia Indirect ... #Hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
+Organomegaly+↑RBC ... • Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology ... #Diagnosis #Oncology