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diagnosis differential management oncology anemia causes algorithm blood hemolysis leukemia product transfusion vasculitis arterial chronic cll common complications cryofibrinogenemia dress
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... blood loss, Acute hemolysis ... Vasculitides, IBD, Celiac disease ... syndrome, POEMS • Reaction ... Diagnosis #Algorithm #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Other: Transfusion reaction ... cold agglutin disease ... - Transfusion reaction ... e.g. sickle cell disease ... differential #diagnosis #hematology
Transfusion Reactions - Summary Cheatsheet • Hemolytic Reaction • Febrile Reactions • Transfusion Related Acute Lung
Transfusion Reactions ... Cheatsheet • Hemolytic ... Reaction • Febrile ... Graft Vs Host Disease ... diagnosis #management #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... Causes: • Liver disease ... • Transfusion reactions ... Diagnosis #causes #classification ... #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... DIC/TTP/HUS - Hemolytic ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Anemia of Chronic Disease ... • Bleeding • Hemolysis ... Renal Disease, Liver ... #Anemia #MCV #Classification ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... AIHA, Transfusion reactions ... , Drugs, Liver Disease ... Urobilinogen #Hemolysis ... Differential #Diagnosis #hematology
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
characterized by extensive skin ... rash in association ... Atypical Lymphocytes ... Skin involvement ... DRESS #Syndrome #dermatology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
maculopapular rash ... Graft Versus Host Disease ... infections with skin ... Borrellia (Lyme disease ... diagnosis #management #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency (CVID ... CVID: Immunodeficiency ... Granulomatous lymphocytic ... and autoimmune hemolytic ... hypogammaglobulinemia #immunology #hematology
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