211 results
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia
Clinical
 - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
Large Granular Lymphocytic ... of autoimmune disease ... morphologic/clinical disease ... LargeGranular #Lymphocytic ... hemepath #pathology #diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Chronic Lymphocytic ... minimal tumor burden Diagnosis ... Vmphocytosis on routine CBC ... chemotherapy for low-risk disease ... hematology #hemeonc #diagnosis
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Graves’ Disease: ... Findings B & T lymphocyte ... hyperplasia Note: B & T lymphocytes ... GravesDisease #pathophysiology ... symptoms #signs #diagnosis
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
phenomenon CLL Diagnosis ... Lymphocytosis on CBC ... cells can indicate disease ... surface molecules: CD5 ... #Leukemia #diagnosis
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
- Differential Diagnosis ... Leukemia (CBC with ... Lymphocytes) ... - Monoclonal Lymphocytes ... #Differential #Diagnosis
Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
reaction - Atopic disease ... lymphomas, Hodgkin disease ... CD3-CD4+ T cells ... , IgG4-related disease ... #Differential #Diagnosis
Pulmonary Infections in HIV-AIDS
Bacterial: 
 • No organism identified, Strep pneumoniae, H. influenzae, S.aureus, Streptococcus Grp
) Fungal: • CD4 ... Parasitic: • CD4 ... Primary pulm HTN, Lymphocytic ... Infectious Diseases ... HIVAIDS #workup #diagnosis
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... cells absent, lymphocyte ... Rich, Lymphocyte ... Classification #pathophysiology ... #Hematology #Diagnosis
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
auto-reactive B and CD ... Sydenham's Chorea Lymphocytes ... RheumaticFever #pathophysiology ... #diagnosis #signs
Lysosomal Storage Disorders

Mucolipidoses
 • I-Cell Disease

Mucopolysaccharidoses
 • Hurler
 • Hunter

Sphingolipidoses
 • Tay Sachs
 • Fabry
 •
Mucolipidoses • I-Cell Disease ... Storage #Disorders #Diseases ... #pathophysiology ... #diagnosis #differential