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diagnosis management differential infectiousdiseases symptoms lifecycle parasite signs treatment causes hematology algorithm neurology msk endocrinology gastroenterology clinical rheumatology cardiology dermatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Lymphocytosis on CBC ... surface molecules: CD5 ... • Richter’s Syndrome ... leukemia • Sezary syndrome
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... morphologically mature B Lymphocytes ... rnature-appearing lymphocytes ... 500/uL clonal B lymphocytes ... Vmphocytosis on routine CBC
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia Clinical - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
Large Granular Lymphocytic ... - Positive: CD2 ... , CD3, CD8 - Loss ... of CD5 and/or CD7 ... LargeGranular #Lymphocytic
Inherited Colorectal Cancer (CRS) Syndromes Adenomatous Polyposis Syndromes: • Familial Adenomatous Polyposis (FAP), Attenuated FAP (AFAP), MUTYH
Colorectal Cancer (CRS) Syndromes ... Adenomatous Polyposis Syndromes ... : • "CRC + Endometrial ... Urinary → Lynch Syndrome ... Cronkhite-Canada (CC
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
• Chronic Lymphocytic ... Leukemia (CBC with ... Lymphocytes) ... - Monoclonal Lymphocytes
Graves’ Disease: Pathogenesis and Clinical Findings B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Findings B & T lymphocyte ... hyperplasia Note: B & T lymphocytes ... GravesDisease #pathophysiology
DRESS Syndrome vs SJS/TEN DRESS • Latency: 2-8 weeks • Rash: Morbilliform • Mucosal involvement: 50% have
DRESS Syndrome vs ... with erosions • CBC ... infiltration by lymphocytes ... more sites • CBC ... SCVMCMed #DRESS #Syndrome
Pulmonary Infections in HIV-AIDS Bacterial: • No organism identified, Strep pneumoniae, H. influenzae, S.aureus, Streptococcus Grp
Parainfluenza • CD4 ... ) Fungal: • CD4 ... Parasitic: • CD4 ... Primary pulm HTN, Lymphocytic ... #differential #CD4
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
prognosis • Nodular Lymphocyte ... cells absent, lymphocyte ... Mixed Cellularity, Lymphocyte ... Rich, Lymphocyte ... Classification #pathophysiology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemia): • Lymphocytes ... develop leukostasis syndrome ... • Tumor lysis syndrome ... CLL (Chronic Lymphocytic ... Leukemia): • Lymphocytes
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