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Jaundice and Kayser-Fleischer Rings in Wilson's Disease

#Jaundice #Kayser #Fleischer #Rings #Wilsons #Disease #clinical #video #ocular #physicalexam
Jaundice and Kayser-Fleischer ... Rings in Wilson's ... Disease #Jaundice ... #Disease #clinical ... video #ocular #physicalexam
Clinical Examination for Liver and Biliary Diseases
1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
Examination for Liver ... Xanthelasma and jaundiced ... Kayser-Fleischer rings in Wilson's ... Edema #biliary #physicalexam ... #cirrhosis #liver
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis of Autoimmune ... ) or metabolic liver ... disease (Wilson ... Possible drug-induced liver ... SMA >1:80 #Autoimmune
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
of Severe Acute Liver ... - Drug-Induced liver ... Hepatitis - Autoimmune ... hepatitis - Wilson ... disease - Hemochromatosis
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... • Ischemia • Autoimmune ... • Wilson's ... • Drugs • Wilson's ... • Cholestatic disease
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
) • Onset of jaundice ... ) or metabolic liver ... disease (Wilson ... disease, alpha ... Possible drug-induced liver
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Schistosomiasis - Autoimmune ... Nonalcoholic fatty liver ... disease - Wilson ... disease Congestive ... Venoocclusive disease
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Hemochromatosis, Wilson's ... Disease, Alpha- ... Other: NAFLD, Autoimmune ... Syndrome, Celiac Disease ... , Infiltrative Disease
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
discomfort Signs: Jaundice ... of associated autoimmune ... disease (e.g. dryness ... disease, Persistent ... Liver biopsy findings
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Hemochromatosis, Wilson's ... disease, Alpha- ... Other: NAFLD, Autoimmune ... HELLP, Celiac disease