818 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology of Tumor Lysis ... TLS) Tumor Cell Lysis ... -> Allantoin (High ... Ca-Phos nephropathy (high
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis vs Tumor Lysis ... immature blasts and high ... rasburicase Tumor Lysis ... Pathophysiology: Lysis ... Spontaneous if high
Hypermagnesemia - Etiologies by Mechanism
Renal Failure 
Excessive Mg Administration 
 - Massive PO intake
Mechanisms - Tumor lysis ... Differential #Diagnosis #High
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... cytotoxic therapies in high-burden ... treatments) occur in high ... wandering_er #Tumor #Lysis
Hypocalcemia - Differential Diagnosis Algorithm - Low and High PTH
LOW PTH - Hypoparathyroid
 - Congenital (Pediatric)
Algorithm - Low and High ... Hypomagnesemia HIGH ... Tumor lysis syndrome
Hyperkalemia: Diagnostic algorithm
Decreased renal potassium excretion
 • Acute renal failure
 • Chronic renal failure
 • Drugs
Increased
transfusion • Tumor lysis ... Normal, Renin High ... hypoplasia Aldosterone high
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
Rhabdomyolysis • Tumor lysis ... glycosides • High
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
phlebotomy High ... release due to cell lysis ... reaction - Tumor lysis ... causes #potassium #high
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
phlebotomy High ... release due to cell lysis ... reaction - Tumor lysis ... causes #potassium #high
Pulmonary Embolism Treatment
Systemic Thrombolysis
 - Exclude contraindications.
 - Indications:
   - Massive PE (definite indication)
indication) - High-risk ... Catheter Directed Lysis