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diagnosis differential causes algorithm clinical management radiology neurology ophthalmology nephrology pulmonary endocrinology oncology pathophysiology cardiology syndrome video gastroenterology hematology physicalexam
Tumor lysis syndrome (TLS) - Pathophysiology: → Massive tumor cell lysis → Release of large amounts of K+,
Tumor lysis syndrome ... Pathophysiology: → Massive tumor ... cell lysis → Release
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology of Tumor ... Lysis Syndrome ... (TLS) Tumor Cell ... Lysis -> Release
Tumor Lysis Syndrome - Workup and Management Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... ICU transfer • Tumor ... lysis kbs every ... MatthewHoMD #TLS #Tumor ... #Lysis #Syndrome
Hyperphosphatemia - Differential Diagnosis Algorithm Transcellular Shift: • Rhabdomyolysis • Tumor Lysis • Metabolic or Respiratory Acidosis
Rhabdomyolysis • Tumor ... Lysis • Metabolic ... Hyperlipidemia • Tumor ... Lysis #Hyperphosphatemia
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis vs Tumor ... Lysis Syndrome ... Lysis Syndrome: ... Pathophysiology: Lysis ... #Lysis #Syndrome
Tumor Lysis Syndrome (TLS) Pathophysiology Culprits: ALL, Burkitt, SCLC Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... worsens above #Tumor ... #Lysis #Syndrome
Causes of Hypermagnesemia Increased magnesium load - Magnesium-containing laxatives, antacids, or enemas - Treatment of pre-edampsia/eclampsia (mothers
untreated) - Tumor ... lysis - Rhabdomyolysis
Hyperkalemia - Differential Diagnosis - Impaired Excretion vs Redistribution Impaired Urinary Excretion - Renal failure -
Hypoaldosteronism Cell Lysis ... - Tumor lysissyndrome
Hypermagnesemia - Etiologies by Mechanism Renal Failure Excessive Mg Administration - Massive PO intake
Mechanisms - Tumor ... lysis syndrome
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... wandering_er #Tumor ... #Lysis #Syndrome
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