22 results
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Still's Disease (AOSD ... maculopapular rash ... synovitis (40%) Treatment ... #rheumatology # ... diagnosis #management #treatment
Maculopapular - Diagnostic Algorithm
Pathophysiology:
- Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
- Pathophysiology ... New-onset fever with rash ... #Diagnosis #Dermatology ... #Rash #Maculopapular ... Targetoid #Algorithm #Differential
Approach to the Rash in a an oncology patient - MINT-C Mnemonic
M - Malignancy: Leukemia cutis,
Approach to the Rash ... Gangrenosum, NEH T - Treatment ... dermatoses #skin #Rash ... #oncology #differential ... MINTC #Mnemonic #dermatology
Erythroderma - Diagnostic Algorithm. Pathophysiology: 1) Extensive cutaneous capillary dilation, results in widespread exfoliation of the
Pathophysiology: ... #Diagnosis #Dermatology ... #Rash #Erythroderma ... Nikolsky #Algorithm #Differential
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
Ferritin >3000 ng/mL ... Treatment - Mild ... : NSAIDS Treatment ... Stills #disease #AOSD ... #diagnosis #rheumatology
Petechiae/Purpura - Diagnostic Algorithm. Pathophysiology: 1) Represent the passage of erythrocytes from the intravascular to extravascular
Pathophysiology: ... #Diagnosis #Dermatology ... #Rash #Petechiae ... Palpable #Algorithm #Differential
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders - Differential ... Responsive to Treatment ... Classification #pathophysiology ... #Hematology #Diagnosis ... #NonHodgkin #differential
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
arthritis, Skin rash ... fraction < 20% Differential ... diagnosis #management #treatment ... #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... sIL-2R >2400 Ul/ml ... Unknown cause Treatment ... diagnosis #management #treatment ... #summary #rheumatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... initiation • Differential ... Renal Failure Treatment ... diagnosis #management #hematology