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diagnosis hematology differential treatment algorithm oncology causes signs nephrology neurology workup disease disorders lupus orthopedics pathophysiology arthritis deficiency guidelines hemolysis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... ALL Symptoms: ... - infiltrates (anemia ... • Tumor lysis syndrome ... ) CLL Symptoms:
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Pelger-Huet, Macrocytic anemia ... • Lymphoid (CLL ... CD23, o CML ... Amy Chung, MD, MSc ... Blood #Disorders #hematology
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... experience some symptoms ... anemia (MCV 80- ... a decrease in all ... than 150,000 per mcL
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Framework for Anemia ... thalassemia • Anemia ... Normocytic" • Anemia ... Myelodysplastic syndrome ... diagnosis #causes #hematology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
/min A - Anemia ... M spike: • CML ... diseases, CML, ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... • Neutropenia, anemia ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... workup #oncology #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Myelodysplastic syndrome ... cells - Sickle cell ... Hemolytic uremic syndrome ... #differential #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Script Signs and symptoms ... Consider stem cell ... #diagnosis #management ... #treatment #hematology
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
malignancy: • Symptoms ... : B-symptoms, bruising ... hepatomegaly • Labs: anemia ... , ↑ MCV, ↑/↓ platelets ... Diagnosis #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... Myelodysplastic syndrome ... myeloid leukemia (CML ... Diagnosis #Causes #hematology
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