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HepatoRenal Syndrome - Pathophysiology

Dr. Edgar V. Lerma @edgarvlermamd - Nephrology Secrets https://amzn.to/34t5DgJ

#HRS #HepatoRenal #Syndrome #Pathophysiology #Diagnosis
HepatoRenal Syndrome ... - Pathophysiology ... #HepatoRenal #Syndrome ... #Pathophysiology ... #AKI
Definitions of AKI, CKD, AKD
Acute Kidney Injury (AKI):
 • Increase in SCr by 2 50% within
: • GFR < 60 ml ... • GFR < 60 ml/min ... : • GFR ≥ 60 ml ... per 1.73 m2 • Stable ... #nephrology #acute
Acute Kidney Injury (AKI) - Common Patterns on Urinalysis
 - Prerenal
 - ATN
 - AIN
 -
Kidney Injury (AKI ... UTI - Nephrotic Syndrome ... - Nephritic Syndrome ... Urinalysis #diagnosis #table ... #comparison #nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
limb Gitelman syndrome ... cell epithelial sodium ... of epithelial sodium ... Defects #Kidney #Nephrology ... #Differential #Table
Initial Clinical and Laboratory Data Base for Defining Major Syndromes in Nephrology

#Major #Syndromes #Nephrology #Diagnosis #Workup
Defining Major Syndromes ... in Nephrology ... #Major #Syndromes ... #Workup #Differential ... #Table
Mechanisms of nephron damage in cardiorenal syndrome
 • Increased renal interstitial pressure
 • Hypoperfusion
 • Reduced
in cardiorenal syndrome ... hypertrophy • Sodium ... release • ↓ Cl ... #Mechanisms #pathophysiology ... #nephrology
Mechanisms of Cocaine induced AKI

 • Rhabdomyolysis
 • Vasculitis
 • Infarction
 • Acute interstitial nephritis
 •
Cocaine induced AKI ... Cocaine #induced #AKI ... #nephrology #pathophysiology ... #table
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
: SIADH, Renal Sodium ... Renal Losses (AKI ... Cirrhosis, Nephrotic syndrome ... differential #diagnosis #table ... #sodium #nephrology
Workup for Hyperphosphatemia - Differential Diagnosis Framework
Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
Workup for Hyperphosphatemia ... Rhabdomyolysis, Tumor lysis syndrome ... Kidney Disease: • AKI ... Diagnosis #Framework #Workup ... #phosphate #nephrology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Workup Algorithm ... Abdominal compartment syndrome ... • Cardio-renal syndrome ... #Workup #Algorithm ... Differential #Diagnosis #nephrology