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diagnosis differential causes algorithm cardiology hematology clinical management cardiac monoclonal gammopathy echocardiogram nephrology oncology pocus table dermatology neurology comparison hepatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MM • WM • MGUS ... • MGCS • MGRS ... Dermato-neuro syndrome) MGRS ... Fibrillar deposits: • Amyloidosis ... CVS+joints) • Amyloidosis
Monoclonal Gammopathy Testing Strengths, Weaknesses and Accuracy Compared - SPEP - IFE - FLC
Protein #Diagnosis #MGRS ... #MGUS #SPEP #IFE
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS ... Renal-centered (ie "MGRS ... #Significance #MGUS
MGRS - Monoclonal Gammopathy of Renal Significance #MGRS #Monoclonal #Gammopathy #Renal #Significance #Diagnosis #Pathology
MGRS - Monoclonal ... Significance #MGRS
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
significance (MGUS ... 1.5 gm/dL) IgM MGUS ... , low-risk MGUS ... 8) light-chain MGUS ... monoclonal #gammopathy #MGUS
Amyloidosis Diagnosis 1) Patient presentation • Cardiac-specific signs of amyloidosis: Diastolic heart failure, Heart failure with preserved
Amyloidosis Diagnosis ... Cardiac-specific signs of amyloidosis ... Noncardiac signs of amyloidosis ... significance (MGUS ... neuropathy, atypical MGUS
Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS) Mayo Clinic Risk Stratification Model. CBC,
significance (MGUS ... monoclonal #gammopathy #MGUS
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Significance (MGUS ... Prevalence M > F MGUS ... IgM MGUS: • Serum ... Light-Chain MGUS ... not defined #MGUS
Rouleaux formation is common in IgM gammopathy and may be particularly striking Genevieve Crane, MD, PhD@evemariecrane #Rouleaux #formation
IgM #gammopathy #MGUS
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Myeloma • MGUS ... Amyloidosis)
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