1797 results
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Monoclonal Gammopathy ... Significance (MGUS ... Ig deposition disease ... w/ monoclonal gammopathy ... #Significance #MGUS
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS)
Fracture, Osteoporosis
 - Increased osteoclast activity and bone resorption
of Monoclonal Gammopathy ... Significance (MGUS ... vaccinations Renal disease ... Ig deposition disease ... #Monoclonal #Gammopathy
Monoclonal Gammopathy of Renal Significance (MGRS)

MGRS
• MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
Monoclonal Gammopathy ... refers to kidney disease ... patients with MGUS ... with monoclonal gammopathy ... #Gammopathy #Renal
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
or polyclonal gammopathy ... Include: • MGUS ... • Heavy chain disease ... plasmacytoma • Castleman disease ... Sarcoidosis) • Liver disease
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Disease ... Cold Agglutinin Disease ... • Autoimmune disease ... IgM monoclonal gammopathy ... significance (MGUS
Monoclonal Gammopathy Testing
Strengths, Weaknesses and Accuracy Compared
 - SPEP 
 - IFE 
 - FLC
Monoclonal Gammopathy ... #Monoclonal #Gammopathy ... Protein #Diagnosis #MGRS ... #MGUS #SPEP #IFE
Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS)
Mayo Clinic Risk Stratification Model. CBC,
of monoclonal gammopathy ... significance (MGUS ... #monoclonal #gammopathy ... #MGUS #Followup
MGRS - Monoclonal Gammopathy of Renal Significance 

#MGRS #Monoclonal #Gammopathy #Renal #Significance #Diagnosis #Pathology
MGRS - Monoclonal ... Gammopathy of Renal ... Significance #MGRS ... #Monoclonal #Gammopathy
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
with monoclonal gammopathy ... significance (MGUS ... 1.5 gm/dL) IgM MGUS ... , low-risk MGUS ... #monoclonal #gammopathy
Rouleaux formation is common in IgM gammopathy and may be particularly striking

Genevieve Crane, MD, PhD@evemariecrane

#Rouleaux #formation
common in IgM gammopathy ... formation #IgM #gammopathy ... #MGUS #Clinical