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Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
significance (MGUS ... /dL) IgM MGUS, low-risk ... MGUS (IgG type, ... 8) light-chain MGUS ... diagnosis #management #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Significance (MGUS ... IgM MGUS: • Serum ... MGUS: • Serum ... protein level (non-IgM ... #Significance #hematology
Rouleaux formation is common in IgM gammopathy and may be particularly striking Genevieve Crane, MD, PhD@evemariecrane #Rouleaux #formation
formation is common in IgM ... Rouleaux #formation #IgM ... #gammopathy #MGUS ... Clinical #Pathology #Hematology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS ... Renal-centered (ie "MGRS ... • Organized Ig ... #Significance #MGUS ... Differential #Diagnosis #hematology
Monoclonal Gammopathy Testing Strengths, Weaknesses and Accuracy Compared - SPEP - IFE - FLC
Protein #Diagnosis #MGRS ... #MGUS #SPEP #IFE
Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS) Mayo Clinic Risk Stratification Model. CBC,
significance (MGUS ... monoclonal #gammopathy #MGUS ... diagnosis #management #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MM • WM • MGUS ... • MGCS • MGRS ... anemia due to cold IgG ... anticoagulant • IgM ... Paraproteinemias #Hematology
Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
1: Monoclonal IgM ... may be seen when IgM ... 2: Monoclonal IgM ... 3: Oligoclonal IgM ... Classification #Types #hematology
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Transferrin • Gamma: IgM ... , IgG, IgA, RF, ... classification #Types #hematology
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
AIHA: - 70%; IgG ... mediated - DAT: IgG ... AIHA: - 20%; IgM ... mediated - DAT: IgG ... Pathophysiology #diagnosis #hematology
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