8 results
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Monoclonal Gammopathy ... (MGUS) - Differential ... Renal-centered (ie "MGRS ... #Gammopathy #Clinical ... #Significance #MGUS
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
tubulopathy • Monoclonal ... gammopathy of renal ... significance (MGRS ... malignancies Treatment ... #Differential #Diagnosis
Monoclonal Gammopathy of Renal Significance (MGRS)

MGRS
• MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
Monoclonal Gammopathy ... ) MGRSMGRS ... patients with MGUS ... Clinical Clues: ... #MGRS #Monoclonal
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS)
Fracture, Osteoporosis
 - Increased osteoclast activity and bone resorption
Significance (MGUS ... antibody - Early treatment ... rituximab (in clinical ... high-risk situations #MGUS ... #Monoclonal #Gammopathy
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... Monoclonal IgM ... gammopathy of undetermined ... significance (MGUS
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Causes of Monoclonal ... : • MGUS • Multiple ... • Heavy chain disease ... changes (POEMS syndrome ... #differential #diagnosis
Clarkson’s Disease - Capillary leak syndrome
Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Capillary leak syndrome ... Relapsing-remitting course +++ Clinical ... edema, compartment syndrome ... Monoclonal gammopathy ... #diagnosis #management
Iliotibial Band Friction Syndrome - MSK Radiology
Imaging Findings:
 • The iliotibial band (ITB) is thickened with
- MSK Radiology ... • Treatment: Conservative ... Findings of chronic disease ... #Radiology #diagnosis ... #msk #clinical