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management differential rheumatology disease gammopathy anemia cancer chronic leukemia lymphocytic mds myelodysplastic significance workup acute agglutinin aki algorithm aplastic apml
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
(MGUS) - Differential ... capillary leak syndrome ... • Schnitzler syndrome ... #Significance #MGUS ... #hematology #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MM • WM • MGUS ... • MGCS • MGRS ... capillary leak syndrome ... ) MGRS: • Fibrillar ... #Diagnosis #Oncology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Significance (MGUS ... Prevalence M > F MGUS ... IgM MGUS: • Serum ... Light-Chain MGUS ... #diagnosis #oncology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Multiple Myeloma and Monoclonal ... plasmacytoma, POEMs syndrome ... #Gammopathies #MGUS ... #diagnosis #hematology ... #oncology
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
tubulopathy • Monoclonal ... significance (MGRS ... sinusoidal obstructive syndrome ... Capillary leak syndrome ... • Tumor lysis syndrome
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... significance (MGUS ... ), CLL, Myeloma ... hemolytic #anemia #hematology
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
Significance (MGUS ... antibody - Early treatment ... rituximab (in clinical ... high-risk situations #MGUS ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... Allogeneic stem cell ... Myelodysplastic #Syndrome ... #Management #treatment ... #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... #workup #oncology ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... immunophenotype Clinical ... fludarabine) 3) Monoclonal ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
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