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differential monoclonal oncology significance agglutinin aki anemia cancer causes classification cold complications disease effusions gap globulin gout hemolytic injury kidney
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
of Clinical Significance ... (MGUS) - Differential ... Renal-centered (ie "MGRS ... #MGUS #Differential ... #Diagnosis #hematology
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
• Monoclonal gammopathy ... significance (MGRS ... change disease • Hematologic ... malignancies Treatment ... #Differential #Diagnosis
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
Significance (MGRS ... ) MGRS • MGRS ... Why Does MGRS Matter ... Clinical Clues: ... microangiopathy Treatment
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
Significance (MGUS ... antibody - Early treatment ... rituximab (in clinical ... high-risk situations #MGUS ... #hematology
Causes of Knee Effusions - Differential Diagnosis Framework Knee Effusion Red Flags: 1. Fever/Chills/Joint pain/Night sweats/Weight loss - DDX: -
- Differential Diagnosis ... - Acute rheumatic ... Effusions: - Hematologic ... #differential #diagnosis ... #msk #physicalexam
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... IgM monoclonal gammopathy ... significance (MGUS ... hemolytic #anemia #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Include: • MGUS ... changes (POEMS syndrome ... inflammation (acute ... #differential #diagnosis ... #hematology
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
sex • Metabolic syndrome ... forefoot, ankles, knees ... Dual-energy CT → MSU ... gout treatment; ... #rheumatology
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