10 results
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
of Clinical Significance ... (MGUS) - Differential ... Renal-centered (ie "MGRS ... #Gammopathy #Clinical ... #Significance #MGUS
Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS)
Mayo Clinic Risk Stratification Model. CBC,
for follow-up of monoclonal ... significance (MGUS ... ) Mayo Clinic Risk ... #MGUS #Followup ... algorithm #diagnosis #management
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
significance (MGUS ... 1.5 gm/dL) IgM MGUS ... , low-risk MGUS ... whom there are no clinical ... algorithm #diagnosis #management
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Can Feature A Monoclonal ... • MM • WM • MGUS ... • MGCSMGRS ... Dermato-neuro syndrome) MGRS ... WAIHA • CAD • PCH
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
- Idiopathic monoclonal ... malignancy (CLL) - Monoclonal ... Viral Infection Clinical ... Such As: • IgM monoclonal ... significance (MGUS
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS)
Fracture, Osteoporosis
 - Increased osteoclast activity and bone resorption
Complications of Monoclonal ... Significance (MGUS ... Renal disease - Monoclonal ... rituximab (in clinical ... high-risk situations #MGUS
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
patients with clinically ... stimulation Clinical ... FLARE) (85% of pts ... predominant) (15% of pts ... sclerosis #diagnosis #management
Bradykinin-mediated Angioedema
Clinical features: Submucosal oedema (face, extremity, genitalia), Laryngeal dyspnea (25% of deaths), Recurrent attacks of
Bradykinin-mediated Angioedema Clinical ... lymphoproliferative disorders (MGUS ... immunology #diagnosis #management
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
> M: 9:1 • 5-6th ... salivary ducts Clinical ... Pulmonary amyloidosis, PAH ... phenomenon (16%) MSK ... Rheumatology #Diagnosis #Management
Pectoralis Major Rupture Injury during Bench Press Exercise
CLINICAL: a rare injury patterns with typical sudden "tear/pop"
Press Exercise CLINICAL ... Inferior to operative management ... Followed by PT/OT ... Rupture #Injury #clinical ... #video #msk #orthopedics