7417 results
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
significance (MGUS ... 1.5 gm/dL) IgM MGUS ... , low-risk MGUS ... (IgG type, M- protein ... whom there are no clinical
Monoclonal Gammopathy Testing
Strengths, Weaknesses and Accuracy Compared
 - SPEP 
 - IFE 
 - FLC
Gammopathy #Testing #Protein ... #Diagnosis #MGRS ... #MGUS #SPEP #IFE
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Significance (MGUS ... IgM MGUS: • Serum ... IgM monoclonal protein ... Serum monoclonal protein ... Urinary monoclonal protein
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... Significance (MGUS ... Renal-centered (ie "MGRS ... Monoclonal #Gammopathy #Clinical ... #Significance #MGUS
Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS)
Mayo Clinic Risk Stratification Model. CBC,
significance (MGUS ... ) Mayo Clinic Risk ... monoclonal #gammopathy #MGUS
Subtypes of Serum Proteins

Pre-albumin (Transthyretin)
Albumin
Globulins
 • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Subtypes of Serum Proteins ... Retinol-binding protein ... Ceruloplasmin, Protein ... SatyaPatelMD #Serum #Proteins
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Feature A Monoclonal Protein ... • MM • WM • MGUS ... • MGCSMGRS ... Dermato-neuro syndrome) MGRS
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Proteinuria >150mg/d protein ... Myeloma • MGUS ... Diabetes • Protein
Rouleaux formation is common in IgM gammopathy and may be particularly striking

Genevieve Crane, MD, PhD@evemariecrane

#Rouleaux #formation
IgM #gammopathy #MGUS ... #Clinical #Pathology
Amyloidosis Diagnosis
1) Patient presentation
 • Cardiac-specific signs of amyloidosis: Diastolic heart failure, Heart failure with preserved
significance (MGUS ... neuropathy, atypical MGUS ... of monoclonal protein