5998 results
Monoclonal Gammopathy Testing
Strengths, Weaknesses and Accuracy Compared
 - SPEP 
 - IFE 
 - FLC
Gammopathy #Testing #Protein ... #Diagnosis #MGRS ... #MGUS #SPEP #IFE
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
significance (MGUS ... 1.5 gm/dL) IgM MGUS ... , low-risk MGUS ... (IgG type, M- protein ... Biopsy #algorithm #diagnosis
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Significance (MGUS ... IgM monoclonal protein ... Serum monoclonal protein ... Urinary monoclonal protein ... Significance #hematology #diagnosis
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
- Differential Diagnosis ... Proteinuria >150mg/d protein ... Myeloma • MGUS ... Diabetes • Protein ... #Differential #Diagnosis
Amyloidosis Diagnosis
1) Patient presentation
 • Cardiac-specific signs of amyloidosis: Diastolic heart failure, Heart failure with preserved
Amyloidosis Diagnosis ... significance (MGUS ... neuropathy, atypical MGUS ... of monoclonal protein ... #Amyloidosis #Diagnosis
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
gamma gap (total protein ... #Gammopathies #MGUS ... #diagnosis #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Feature A Monoclonal Protein ... • MM • WM • MGUS ... • MGCSMGRS ... Dermato-neuro syndrome) MGRS ... #Differential #Diagnosis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Elevated Globulin - Protein ... Gap (Total Protein ... • (Total protein ... Gammopathy Include: • MGUS ... #differential #diagnosis
Monoclonal Gammopathy of Renal Significance (MGRS)

MGRS
• MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
) MGRSMGRS ... patients with MGUS ... light-chain ratio Diagnostic ... • Serum/urine protein ... #Significance #Diagnosis
Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS)
Mayo Clinic Risk Stratification Model. CBC,
significance (MGUS ... monoclonal #gammopathy #MGUS ... Followup #algorithm #diagnosis