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Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Glomerulonephritis (MPGN ... dysmorphic RBC, RBC casts ... Complement-Mediated MGPN ... , CFHR5 neph) MPGN ... Glomerulonephritis #MPGN
Intrinsic Renal Disease - Differential Diagnosis Vascular: • Macrovascular: Renal artery occlusion, Fibromuscular disease • Microvascular: TTP/HUS,
, Amyloidosis, MPGN ... • Nephritic: RPGN ... , IgA, Alport, MPGN
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Glomerulonephritis (RPGN ... ) RPGN has three ... pathophysiologic causes ... Complement: Post-strep GN ... StanfordChiefs #RPGN
Recurrent / Breakthrough DVT During Anticoagulation Subtherapeutic Anticoagulation Hypercoagulable State - Antithrombin deficiency - Hypercoagulability ot
- APLS - MPN ... Structural - Pelvic masses
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
basement membrane; GN ... atypical HUS; MPGN ... cell/white cell casts ... Nephrocalcinosis causes
Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Liver, kidney (MPGN
Tachypnea - Differential Diagnosis Framework Definitions • Tachypnea: Respiratory rate > 20/min, shallow breathing in adults •
Respiratory rate > 20/min ... Respiratory rate > 20/min ... PVFM) Cardiac Causes ... Hematologic Causes ... acidosis of any cause
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
Glomerulonephritis (RPGN ... post-infectious GN ... Glomerulonephritis #RPGN
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
C3 ↓ C4 ↓↓ • MCGN
Childhood Immunization Schedule: Why we immunize • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
URT inflammation causes ... severe swelling causes ... severe swelling causes ... within CNS causing MN ... > Inflammation causes
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