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Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Glomerulonephritis (MPGN ... Mesangiocapillary GN ... Complement-Mediated MGPN ... , CFHR5 neph) MPGN ... Glomerulonephritis #MPGN
Intrinsic Renal Disease - Differential Diagnosis Vascular: • Macrovascular: Renal artery occlusion, Fibromuscular disease • Microvascular: TTP/HUS,
, Amyloidosis, MPGN ... • Nephritic: RPGN ... , IgA, Alport, MPGN
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Glomerulonephritis (RPGN ... ) RPGN has three ... Complement: Post-strep GN ... StanfordChiefs #RPGN
Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Liver, kidney (MPGN
Recurrent / Breakthrough DVT During Anticoagulation Subtherapeutic Anticoagulation Hypercoagulable State - Antithrombin deficiency - Hypercoagulability ot
- APLS - MPN
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
Glomerulonephritis (RPGN ... post-infectious GN ... Glomerulonephritis #RPGN
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
C3 ↓ C4 ↓↓ • MCGN
Oxygen Delivery Systems Nasal Cannula: • Flow: 1 - 6 L/min • FiO2: 25 - 40% (-4%/L
Flow: 1 - 6 L/min ... of flow) Face Mask ... Flow: 5 - 10 L/min ... ~40% Venturi Mask ... Flow: 2 - 15 L/min
Acanthocyte on Urine Microscopy Not a spaceship, not a UFO, just an acanthocyte caught “flying” in dark
in patient with clinical ... presentation of RPGN ... Urine #Microscopy #clinical
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 Reduction of Anterior Shoulder Dislocation This young man presented to the ER with a Shoulder Dislocation. He
This young man ... Dislocation #Anterior #clinical ... #physicalexam #msk
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