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Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Glomerulonephritis (MPGN ... Complement-Mediated MGPN ... , CFHR5 neph) MPGN ... anti-phospholipid syndrome ... Glomerulonephritis #MPGN
Intrinsic Renal Disease - Differential Diagnosis Vascular: • Macrovascular: Renal artery occlusion, Fibromuscular disease • Microvascular: TTP/HUS,
, Amyloidosis, MPGN ... • Nephritic: RPGN ... , IgA, Alport, MPGN
Recurrent / Breakthrough DVT During Anticoagulation Subtherapeutic Anticoagulation Hypercoagulable State - Antithrombin deficiency - Hypercoagulability ot
- APLS - MPN ... - May-Thurner syndrome
Eosinophilia - Differential Diagnosis Algorithm Idiopathic Eosinophilia Primary Eosinophilia: • Primary hypereosinophilic syndrome • Eosinophilic Leukemia • MPN/MDS
hypereosinophilic syndrome ... Eosinophilic Leukemia • MPN ... Hyper-lgE (Job) syndrome ... ABPA), Gleich syndrome ... Infectious: Loeffler syndrome
Multiple Endocrine Neoplasias (MEN syndromes) MEN I • Hyperparathyroidism • Hypercalcemia • Possible ZE syndrome • Various
Endocrine Neoplasias (MEN ... syndromes) ... • Possible ZE syndrome ... • Cushing syndrome ... Galactorrhea MEN
Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Liver, kidney (MPGN
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
C3 ↓ C4 ↓↓ • MCGN
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
basement membrane; GN ... hemolytic-uremic syndrome ... atypical HUS; MPGN ... proteinuria #nephrotic #syndrome
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Glomerulonephritis (RPGN ... ) RPGN has three ... Complement: Post-strep GN ... StanfordChiefs #RPGN
Spinal Cord Injury Syndromes Complete, Incomplete, Paraplegia, Tetraplegia Incomplete Spinal Cord Syndromes: - Brown Sequard Syndrome - Anterior
Spinal Cord Injury Syndromes ... Brown Sequard Syndrome ... Anterior Cord Syndrome ... Posterior Cord Syndrome ... - Central Cord Syndrome
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