32 results
Intrinsic Renal Disease - Differential Diagnosis
Vascular:
 • Macrovascular: Renal artery occlusion, Fibromuscular disease
 • Microvascular: TTP/HUS,
, Amyloidosis, MPGN ... • Nephritic: RPGN ... , IgA, Alport, MPGN
Acanthocyte on Urine Microscopy

Not a spaceship, not a UFO, just an acanthocyte caught “flying” in dark
Acanthocyte on Urine ... a UFO, just an acanthocyte ... presentation of RPGN ... VelezNephHepato #Acanthocyte
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Glomerulonephritis (MPGN ... Complement-Mediated MGPN ... , CFHR5 neph) MPGN ... Glomerulonephritis #MPGN
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Glomerulonephritis (RPGN ... ) RPGN has three ... StanfordChiefs #RPGN
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
Glomerulonephritis (RPGN ... Glomerulonephritis #RPGN
Acanthocytes in motion on Urine Microscopy - Phase Contrast

Dr. Jay R. Seltzer @jrseltzer

#Acanthocytes #motion #Urine #Microscopy
Acanthocytes in ... Seltzer @jrseltzer #Acanthocytes
Cryoglobulinemia Classification Types

Type 1: Monoclonal IgM (rarely IgG/lgA)
 • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Liver, kidney (MPGN
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
atypical HUS; MPGN ... high-power field + acanthocytes
Another view of acanthocytes under darkfield illumination after removal of light filter over field diaphragm

Dr. Jay
Another view of acanthocytes ... @jrseltzer #acanthocytes
A red blood cell (red arrow) is seen crossing the basement membrane (blue arrow) and losing
mechanisms proposed for acanthocyte ... #acanthocyte #formation