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video pocus physicalexam ultrasound cardiology diagnosis radiology ophthalmology neurology echocardiogram photo msk ocular sign management orthopedics ucsdh pulmonary sports dermatology
Monkeypox What? Monkeypox virus belongs to the family Poxviridae, subfamily Chordopoxvirinae, and genus orthopoxvirus Viral zoonotic disease that is
with someone with Mpox ... three weeks Clinical ... inguinal region • Mpox-related ... with confirmed mpox ... #Monkeypox #MPOX
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
40, F:M 9:1 • Clinical ... - pANCA anti-MPO
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... - pANCA anti-MPO ... 40, F:M 9:1 • Clinical ... - pANCA anti-MPO
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
associated with MPO ... polyangiitis - MPO ... polyangiitis - MPO ... Renal-limited - MPO ... #CANCA #PANCA #MPO
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
polyangiitis - MPO ... PR3 (80-90%) > MPO ... involvement - PR3>MPO ... Churg-Strauss) - MPO ... Anti-GBM disease - MPO
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
myeloperoxidase (MPO-ANCA ... present in >90%, MPO ... Granulomas - MPO ... (10-40% ANCA +MPO ... 100 % Commonly MPO-ANCA
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
MPA > eGPA • MPO-ANCA
Lymphocutaneous Sporotrichiosis Infection Landscaper w/ painless nodular rash of arm present for months wax and wane; diagnosis? Lymphocutaneous
staph aureus, cow pox ... Sporotrichiosis #Infection #clinical
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
CD34, HLA-DR, MPO
ANCA Associated Vasculitis (AAV) - Auto-antibodies and Differential Diagnosis MPA → usually p-ANCA GPA → usually c-ANCA EGPA →
50% P-ANCA (MPO
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