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Hypocalcemia - Workup Algorithm

Dr Nikhil Lohiya - NEPHKIDS 2020 @NEPHKIDS1

#Hypocalcemia #Workup #Algorithm #differential #diagnosis #endocrinology #causes
Hypocalcemia - Workup ... #Workup #Algorithm ... #differential # ... diagnosis #endocrinology ... #causes #calcium
Hypercalcemia Workup and Differential Diagnosis Framework
1) Determine whether PTH-dependent
2) Assess for other hormonal causes
3) Assess for
Hypercalcemia Workup ... and Differential ... #Workup #Differential ... #Diagnosis #algorithm ... #endocrinology
Causes of Hypercalcemia
Hypercalcemia due to increased bone Ca2+ resorption:
 • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... Hypercalcemia ... calcium)-alkali syndrome ... #Causes #differential ... calcium #high #endocrinology
Causes of Hypercalcemia - Differential Diagnosis Algorithm
 • Primary Hyperparathyroidism 
 • Possible Familial Hypocalciuric Hypercalcemia
Causes of Hypercalcemia ... - Differential ... Diagnosis Algorithm ... #Differential # ... #Causes #endocrinology
Workup of Hypercalcemia - Differential Diagnosis Algorithm
High or Normal PTH:
 • Hyperparathyroidism: Parathyroid adenoma, Parathyroid hyperplasia,
Workup of Hypercalcemia ... - Differential ... Diagnosis Algorithm ... #Differential # ... Diagnosis #Algorithm
Hypercalcemia - Differential Diagnosis Algorithm
Elevated PTH (High or normal):
 • Primary Hyperparathyroidism
 • Familial Hypocalciuric Hypercalcemia
Low
Differential Diagnosis ... Algorithm Elevated ... #Differential # ... Diagnosis #Algorithm ... #causes #endocrinology
Causes of Hypercalcemia
Parathyroid hormone–dependent
Primary hyperparathyroidism
Familial hypocalciuric hypercalcemia
Lithium-associated
Tertiary hyperparathyroidism
Genetic disorders (e.g., multiple endocrine neoplasia type 1 or
Causes of Hypercalcemia ... hypocalciuric hypercalcemia ... Other humoral syndromes ... #Causes #Differential ... #Diagnosis #Endocrinology
Hypercalcemia Evaluation
1) Clinical clues
 - Is the patient symptomatic?
 - Family history?
 - Have you done
Hypercalcemia Evaluation ... 1) Clinical clues ... #workup #differential ... #diagnosis #endocrinology ... elevated #evaluation #workup
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
Algorithm for workup ... hemolytic uremic syndrome ... thrombocytopenia, Hematology ... #Diagnosis #Differential ... #Algorithm #Thrombocytopenia
Hypocalcemia Workup - Differential Diagnosis Algorithm
 • Low Magnesium, High Magnesium - Functional Hypoparathyroidism
 • High
Hypocalcemia Workup ... - Differential ... Diagnosis Algorithm ... metastases, Hungry bone syndrome ... #Workup #Differential