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hematology differential neurology oncology causes korsakoff algorithm b1 calculation chronic cll copper encephalopathy index leukemia lymphocytic management mds myelodysplasia myelodysplastic
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
x (Hct / 45) / Maturation ... Factor The maturation ... released in the peripheral ... marrow failure: Aplastic ... #differential #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... : • Peripheral ... anemia Treatment ... #hematology #diagnosis
Risk Factors and Signs of Copper Deficiency Risk Factors: • Gastrointestinal: Previous upper bowel resection/bariatric surgery, Inflammatory
of Copper Deficiency ... diarrhoea, Short bowel syndrome ... dental fixatives, Treatment ... Neurological: Myelopathy, Peripheral ... #diagnosis #signs
Korsakoff Syndrome Clinical Findings: • Confabulation: Usually initial phase of the disease • Anterograde amnesia: Memory impairment
Korsakoff Syndrome ... • Anterograde amnesia ... presentation of Thiamine deficiency ... Encephalopathy Treatment ... #neurology #diagnosis
Etiologies of Peripheral Neuropathy • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism • Medication-induced: ART, Antibiotics,
Etiologies of Peripheral ... Nutritional: DiabetesB12 deficiency ... Paraprotein-associated (POEMS syndrome ... #differential #diagnosis ... #causes #neurology
Wernicke's Encephalopathy vs Korsakoff Syndrome - Thiamine Deficiency Wernicke's encephalopathy is a neurological condition due to longstanding
- Thiamine Deficiency ... is Korsakoff's syndrome ... and retrograde amnesia ... #diagnosis #comparison ... #neurology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
bone marrow and peripheral ... • Aplastic Anemia ... or folic acid deficiency ... • Copper deficiency ... #diagnosis #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Algorithm Peripheral ... Acute hemolysis, deficiency ... anemia, Rebound ... effect from treatment ... Kawasaki, Nephrotic syndrome
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... cytometry • Peripheral ... • Neutropenia, anemia ... Pure red cell aplasia ... microglobulin Treatment
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
- Differential Diagnosis ... endocrine: Vitamin B12 deficiency ... Lesions Of The Peripheral ... Lack of UMN/LMN signs ... #neurology
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