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diagnosis hematology causes algorithm rheumatology classification treatment blood cardiology disease endocarditis erythematosus extravascular hemolysis intravascular lung lupus mcv oncology product
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... DAT (-) → G6PD Deficiency ... Recent travel/Fevers ... , DAT (-) → Infection ... #Anemia #Differential
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
x (Hct / 45) / Maturation ... Factor The maturation ... (e.g. cancer, infection ... , G6PD deficiency ... #differential #
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... Mycoplasma pneumoniae infection ... G6PD deficiency) ... spherocytosis) • Infections ... Extravascular #Causes #differential
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... inclusions - If infection ... bartonella (oroya fever ... #Anemia #Differential
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... -100): • Non-hemolytic ... , CKD • Hemolytic ... Macroangiopathic, Infections ... MCV #Algorithm #Differential
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... • PK deficiency ... circulation - Infections ... anemia • ... Extravascular #Differential
Rodent-associated Bacterial infections: Leptospirosis, Rat-bite fever, Tularemia, Plague #rodent #infections #leptospirosis #tularemia #ratbitefever #plague #rats #infectiousdisease #fever #differential #diagnosis #management #treatment #table
Leptospirosis, Rat-bite fever ... #rodent #infections ... plague #rats #infectiousdisease ... #fever #differential ... #diagnosis #management
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... 80 fL) • Iron Deficiency ... • Bleeding • Hemolysis ... Inflammation, Chronic Infection ... Classification #Differential
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... anemia, PNH, immune ... • Toxins • Infection ... myocarditis, rheumatic fever ... Dehydrogenase #Elevated #differential
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Diseases: • GATA2 deficiency ... • Fanconi’s anemia ... Antibody-mediated hemolysis ... Infections:
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