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differential management classification approach ascorbicacid cobalamin elevatedmcv fatigue macrocytic macrocytosis mcv mds myelodysplasia myelodysplastic neutropenia oncology pancytopenia platelets scurvy syndromes
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined ... #Algorithm #Causes
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Inflammatory: • IBD ... effect following treatment ... anemia #Thrombocytosis ... #Algorithm #Causes
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Algorithm Normal ... and Folate Deficiency ... #Algorithm #Causes ... #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Megakaryopoiesis • B12 ... Folate Deficiency ... #Algorithm #Causes ... #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... (>100 fL) • B12 ... Folate Deficiency ... #Algorithm #Causes ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Acute hemolysis, deficiency ... anemia, Rebound ... effect from treatment ... Vasculitides, IBD ... #Algorithm #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Algorithm Blood ... • B12/Folate ... #Algorithm #Causes ... #Hematology
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
Crohn's > UC Anemia ... • Supplement folate ... restricted diet/deficiency ... /other causes • ... #Algorithm #diagnosis
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... diarrhea related to IBD ... Check for IF ab Treatment ... #nutrition
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
) - Diagnosis and ... lead to iron and folate ... , or any other cause ... vasculitis Treatment ... #Nutrition #Diagnosis
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