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diagnosis algorithm anemia causes gradient liver saag disease hepatitis oncology serum thrombocytosis aflp agglutinin atlas bilirubinemia calculation chemistry cirrhosis classification
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
fragmentation hemolysis ... toxin-mediated hemolytic-uremic ... • Mechanical hemolysis ... #diagnosis #hematology ... #hemolysis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... Microangiopathic hemolytic ... purpura (TTP), Hemolytic ... #diagnosis #hematology
Diagnosis of ascites according to the serum ascites albumin gradient (SAAG) SAAG ≥ 1.1: - Ascitic protein
albumin gradient ... Late Budd-Chiari syndrome ... leak, Nephrotic syndrome ... #albumin #gradient ... #hepatology #differential
Ascites Differential Diagnosis Table - Serum Ascites Albumin Gradient (SAAG) SAAG ≥ 1.1: • Cirrhosis • Portal
Ascites Differential ... Albumin Gradient ... • Nephrotic syndrome ... #Differential # ... Gradient #SAAG #hepatology
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic
thrombocytopenic purpura/hemolytic ... uremic syndrome ... thrombocytopenia, Hematology ... #Diagnosis #Differential
Isolated Hyperbilirubinemia - Differential Diagnosis Algorithm Direct Hyperbilirubinemia: Dubin-Johnson Syndrome, Rotor Syndrome Indirect Hyperbilirubinemia: - Trauma, Hematoma,
Hyperbilirubinemia - Differential ... , Rotor Syndrome ... Count Abnormal: Hemolysis ... Hyperbilirubinemia #Isolated #Differential ... Diagnosis #Algorithm #hepatology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Factor The maturation ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... Production #Index #hematology ... #anemia #differential
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Jaundice - Differential ... Production • Hemolysis ... • Gilbert's Syndrome ... Crigler-Najjar Syndromes ... Algorithm #Causes #Hepatology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH, Evans Syndrome ... Urobilinogen #Hemolysis ... #Differential # ... Diagnosis #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Wiskott-Aldrich syndrome ... Antibody-mediated hemolysis ... #Pancytopenia #Differential ... #Diagnosis #Hematology
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