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Iron Deficiency Anemia vs Anemia of Chronic Disease - Laboratory Testing SUMMARY: - RDW, FEP, serum iron,
of Chronic Disease ... - Laboratory Testing ... , saturation-worthless ... #Chronic #Disease ... #Laboratory #Testing
Iron Panel Interpretation Iron deficiency - ↓ Iron, ↑-nl Transferrin / TIBC, ↓ Transferrin Saturation, ↓
↓ Transferrin Saturation ... , ↓ Ferritin Anemia ... of chronic inflammation ... deficiency + Chronic ... differential #hematology #laboratory
For an elderly patient with multiple comorbidities it can be challenging to determine if their anemia
determine if their anemia ... is secondary to iron ... of chronic disease ... benefit from IV iron ... #Transferrin #Saturation
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (<80 fL) • Iron ... of Chronic Disease ... of Chronic Disease ... Diagnosis #Algorithm #Causes
Gastrointestinal Evaluation of Iron Deficiency Anemia In patients with anemia, diagnose iron deficiency if: • Ferritin <
Deficiency Anemia ... • Additional laboratory ... inflammation or chronic ... Test for celiac disease ... change medical management
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
x (Hct / 45) / Maturation ... Factor The maturation ... deficiencies: Iron ... deficiencies: Chronic ... kidney disease,
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... RBC turnover • Iron ... • Asplenia Laboratory ... • Hemolytic anemia ... End-stage renal disease
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
RBCs on Smear • Chronic ... MCH, MCHC, Serum Iron ... • Anemia of Chronic ... Disease • Marrow ... Diagnosis #Algorithm #Causes
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... Inflammation: IBD, Chronic ... disease (↑ hepcidin ... #Deficiency #Causes ... differential #diagnosis #anemia
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Microcytic" • Iron ... of chronic kidney ... disease, Acute ... Alcohol use, Liver disease ... differential #diagnosis #causes
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