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management rheumatology differential syndrome algorithm erythematosus leukemia sle symptoms systemic chronic classification cll hemeonc hemophagocytic hlh lymphocytic lymphohistiocytosis workup activation
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
- Differential Diagnosis ... deficiency • Fanconi’s anemia ... • Leukemia • Lymphoma ... : • Systemic lupus ... #Hematology
Suspected Celiac Disease - Diagnosis Algorithm Celiac disease suspected: • Signs and symptoms of celiac disease •
- Diagnosis Algorithm ... suspected: • Signs ... Iron-deficiency anemia ... unresponsive to treatment ... collagenous sprue) • Lymphoma
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Hemolytic anemia ... auto-immune, Infectious diseases ... sclerosis, Still's disease ... autoantibodies #signs ... #differential #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Microangiopathic hemolytic anemia ... usually IgG) (e.g. lupus ... , CLL, lymphoma, ... #hematology #anemia
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Metastatic cancer, Lymphoma ... Vasculitides, IBD, Celiac disease
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... cells can indicate disease ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
pain (20%) Renal disease ... ) Blood (75%): Anemia ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Immune hemolytic anemia ... number of sites of disease ... Treatment • Early ... #hematology #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
5) Symptoms of anemia ... to large cell lymphoma ... chemotherapy for low-risk disease ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Angioimmunoblastic T-cell lymphoma ... vein thrombosis Hematologic ... lymphopenia, low PLT • Anemia ... Erythematosus #Diagnosis
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