27 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... uremic syndrome ... • Intrinsic RBC ... #hematology #anemia
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Diagnosis Framework ... Autoimmune: Warm AIHA, Cold ... Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell anemia ... #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
- Differential Diagnosis ... Warm AIHA • Cold ... elliptocytosis - RBC ... anemia • ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Cell Agglutinate: Cold ... autoimmune hemolytic ... cold hemoglobinuria ... #differential #diagnosis ... #hematology #microscopy
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Agglutinin Syndrome ... Diagnosis: • hemolytic ... anemiaCold ... Blood smear - RBC ... #anemia #hematology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... PD deficiency, Pulmonary ... uremic syndrome ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... Agglutination - Cold ... #Anemia #Differential ... #workup #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
is the diagnostic ... result in severe anemia ... schistocytes, nucleated RBCs ... anemia Indirect ... #Workup #Hematology
Iron Deficiency Anemia - Differential Diagnosis Algorithm

Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR

 • Blood loss:
extravascular) hemolysis ... athletic training, Pulmonary ... Gastrectomy, WHDA syndrome ... diet, Alcoholism, Tea-toast ... Algorithm #ferritin #hematology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
- Differential Diagnosis ... concentrations in: RBCs ... Legionnaires disease • Pulmonary ... • Tumor lysis syndrome ... #differential #diagnosis