8 results
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
- Elevated Platelet ... blood loss, Acute hemolysis ... , deficiency anemia ... Kawasaki, Nephrotic syndrome ... #Platelets #Differential
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
) Three syndromes ... defects. 1) HELLP (Hemolysis ... Elevated Liver tests ... , Low Platelets) ... #diagnosis #table
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... iron deficiency, hemolysis ... Myelodysplastic syndrome ... Diagnosis #Causes #hematology
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Pregnancy Three syndromes ... defects. 1) HELLP (Hemolysis ... Elevated Liver tests ... , Low Platelets) ... TTPHUS #HELLP #AFLP
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
value is low, tests ... hemorrhage and hemolysis ... intravascular hemolysis ... out an immune hemolytic ... the severity of hemolysis
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Diagnosis: • hemolytic ... • Compensated hemolysis ... intravascular hemolysis ... agglutinin #disease #hemolytic ... #anemia #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell anemia ... Laboratory Tests ... Urobilinogen #Hemolysis
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... #rheumatology #