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management oncology syndrome comparison complications differential differentiation gait leukostasis lysis mds msk myelodysplasia myelodysplastic pagetsdisease reactions rheumatology syndromes table taco
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... common • Imaging: CXR ... : >3 symptoms, or ... sepsis), PE, DAH, CHF ... #hematology #oncology
Trendelenburg Gait: Pathogenesis and clinical findings Skeletal Pathology of the Hip • Arthritis • Congenital hip dysplasia
tears of gluteus medius ... Greater Trochanter Fracture ... Trendelenburg #Gait #pathophysiology ... #causes #symptoms ... #signs #diagnosis
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
without other cause ... ARDS to explain symptoms ... : Age>60, CKD, CHF ... fluid balance, and CXR ... #diagnosis #comparison
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... , dyspnea, +/- CXR ... WBC >100k, + lab signs ... Syndrome #TLS #diagnosis ... #management #hematology
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
-> Pathologic fractures ... Heart Failure (CHF ... PagetsDisease #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... Exposure to heavy metal ... characteristic feature ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... primary condition MEDIUM ... • Progressive symptoms ... tract, and often causes ... #Rheumatology
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