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diagnosis algorithm rheumatology management oncology systemic cd4 erythematosus icl idiopathic lupus lymphocytopenia lymphopenia macrophage mas mds myelodysplasia myelodysplastic naildisorders neutropenia
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... • Marrow Aplasia ... Hypersplenism • Secondary ... RA, SLE, PRV, Chronic ... #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic ... Anemia • Toxic ... Autoimmune • ITP • SLE ... Non-lmmune: • HELLP Syndrome ... #Hematology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Abnormality • SLE ... Iron deficiency anemia ... Discoloration • Medications ... • Nephrotic syndrome ... #dermatology #Differential
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Anemia Clinical ... and petechiae Causes ... #hematology #diagnosis
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... leakage of RBC's secondary ... - Hemolytic anemia ... #Diagnosis #hematology ... #nonpalpable #dermatology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
- Differential ... Chediak-Higashi syndrome ... Megaloblastic anemia-rare ... white blood cell aplasia ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... Classified among the secondary ... erythematosus [SLE ... with leukopenia, anemia ... #Management #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
DDX: Rule Out Secondary ... Causes • Anemia ... • Aplastic Anemia ... blood count with differential ... #diagnosis #hematology
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
Autoimmune (Sjogren, SLE ... Heme (lymphoma. aplasia ... ICL #diagnosis #hematology ... #Differential # ... Causes #lymphocytopenia
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... permanent alopecia Differential ... lymphopenia, low PLT • Anemia ... Chronic B-cell activation ... and/or medications
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