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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Thrombotic Microangiopathies ... Lupusreference #TMAs #Thrombotic ... Erythematosus #SLE #hematology ... #rheumatology # ... differential #diagnosis #causes
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease
Increased Thrombosis 
Increased Platelet-Vesset Wall Interaction 
 •
Driving Increased Thrombosis ... Disease Increased Thrombosis ... Bleeding #Clot #Cirrhosis ... #Pathophysiology ... #Hepatology #Liver
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework

STRUCTURAL:
 - PFO: paradoxical emboli
 - Popliteal
Causes of Arterial ... and Venous Thrombosis ... artery aneurysm: Causes ... TTP - Arterial thrombosis ... Diagnosis #clots #hematology
Causes of Portal Hypertension According to Site of Vascular Obstruction
1) Prehepatic pre-sinusoidal: Portal vein thrombosis due
Causes of Portal ... pre-sinusoidal: Portal vein thrombosis ... or secondary to cirrhosis ... 3) Sinusoidal: Cirrhosis ... #hepatology
Causes of Pleural Effusion - Differential Diagnosis Algorithm
Transudate - Hydrostatic
 • Congestive heart failure
 • Constrictive
Causes of Pleural ... - Oncotic • Cirrhosis ... • Uremia • Meigs ... Diagnosis #Algorithm #Hepatology ... #causes
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
to non-cirrhotic ... Primary biliary cirrhosis ... • Portal vein thrombosis ... Differential #Diagnosis #causes ... #hepatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Venous Thrombosis ... considered in all cases ... coagulation and other causes ... Venous #Arterial #pathophysiology ... #hematology #differential
Causes of Ascites - Differential Diagnosis Algorithm
Portal Hypertension - Prehepatic:
 • Portal vein thrombosis
 • Splenic
Causes of Ascites ... • Portal vein thrombosis ... - Hepatic: • Cirrhosis ... Diagnosis #Algorithm #Hepatology ... #causes
Portal Vein Thrombosis (PVT) Treatment Algorithm
 - If concern for ischemic: anti-coag+multidisciplinary care
 - W/o cirrhosis+recent
Portal Vein Thrombosis ... multidisciplinary care - W/o cirrhosis ... tx - Cirrhosis ... : case-by-cased ... management #Algorithm #hepatology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Causes of Splenomegaly ... Congestive • Cirrhosis ... Spherocytosis • Acquired causes ... Diagnosis #Algorithm #Causes ... #Hematology